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pentobarbital will lower the level or effect of parecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.Contraindicated (1)pentobarbital will lessen the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine'